USP9x-deficient DLD-1 (with or without p53) cell line
Invented at Johns Hopkins University
- Datasheet
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- Inventor Info
Info
| Catalogue Number | 156404 |
| Antigen/Gene or Protein Targets | USP9X and p53 |
| Parental Line | DLD-1 |
| Tissue | Colon |
| Disease Keywords | Cancer |
| Model | Knock-Out |
| Relevance |
This cell line presents an opportunity to study the effect of loss of apoptotic control on colorectal cancer cells. Study of deubiquitinase Ups9X could act as a leap towards understanding apoptotic regulation and potentially lead to new drug targets for cancer. In this technology, the gene USP9X is knocked out of two colorectal DLD-1 cells. The gene knockout has been performed by rAAV-mediated homologous recombination. The technology also consists of a double knockout line without USP9X and p53, a tumor suppressor gene. |
| Research Area | Cancer, Drug Discovery & Development |
