Mutant DISC1 cell line
Invented at Johns Hopkins University
- Datasheet
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- Inventor Info
Info
| Catalogue Number | 156416 |
| Antigen/Gene or Protein Targets | disrupted-in-schizophrenia 1 (DISC1) |
| Parental Line | PC12 |
| Disease Keywords | Schizophrenia |
| Relevance | To evaluate the effects of a predicted protein, mutant disrupted-in-schizophrenia 1 (DISC1), stable PC12 cell clones with inducible expression of mutant or full-length human DISC1 (hDISC1) have been generated. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable expression of full-length and truncated hDISC1, allowing for a regulated expression of hDISC1 in homogenous populations of cells. Inducible expression of DISC1 in PC12 cells is a valuable in vitro model for further studying the molecular mechanisms likely due to loss of function of DISC1 relevant to the pathogenesis of major mental illnesses. |
| Research Area | Neurobiology, Drug Discovery & Development |
