Homozygous Mutant DISC1 (1001) mouse
Invented at Johns Hopkins University
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 156432 |
| Antigen/Gene or Protein Targets | DISC1 |
| Disease Keywords | Schizophrenia and psychiatric illnesses |
| Model | Mutant |
| Relevance | This homozygous mouse strain (1001) carries mutant hDISC1 without gross developmental defects. In this strain, the expression of mutant hDISC1 is restricted to forebrain regions using TET-off system under the control of CAMKII. In addition, the expression can be suppressed by feeding the mice with doxycycline (DOX). These transgenic animals allow selective control of mutant hDISC1 expression in forebrain neurons and, herein provide a valuable research tool to study pathogenesis of schizophrenia and to conduct experimental therapeutics for the disease. This line is on a mixed background (B6; SJL; CBA). |
| Mouse Genetic Background/Cross History | B6; SJL; CBA |
| Zygosity | Homozygous |
| Research Area | Neurobiology, Drug Discovery & Development |
References: 2 entries
Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.
Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.
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References: 2 entries
Pogorelov et al. 2012. Neuropharmacology. 62(3):1242-51. PMID: 21315744.
Abazyan et al. 2010. Biol Psychiatry. 68(12):1172-81. PMID: 21130225.
Add a reference
