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- References (2)
- Inventor Info
Info
| Catalogue Number | 157948 |
| Antigen/Gene or Protein Targets | CXCR3 |
| Disease Keywords | allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth |
| Model | Knock-In |
| Relevance | Chemokines are typically small, secreted molecules that participate in leukocyte trafficking, recruitment, and activation. They also play roles in normal and pathological processes including allergic responses, infectious and autoimmune disease, angiogenesis, inflammation, and tumor growth and metastasis. CXC chemokine receptor 3 (CXCR3) is expressed by natural killer cells, neutrophils, T cells and plasmacytoid dendritic cells. CXCR3 ligands are produced in extremely high levels during inflammation and infection, but they may also be possible targets for development of therapeutics for autoimmune and cancer diseases. There is a significant need for animal models to track and investigate CXCR3 expressing cells for diagnostic and therapeutic tool development. |
| Research Area | Cancer, Immunology |
References: 2 entries
Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.
Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.
Add a reference
References: 2 entries
Cohen et al. 2013. PLoS Pathog. 9(10):e1003706. PMID: 24130498.
Oghumu et al. 2013. J Immunol. 190(5):2229-40. PMID: 23338236.
Add a reference
Inventor Information
Inventors
|
Abhay Satoskar |
