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Polyclonal Antibodies

Anti-sTDP43 polyclonal antibody

Invented by Sami Barmada
Invented at University Of Michigan
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Figure published: Weskamp K, Tank EM, Miguez R, McBride JP, Gómez NB, White M, Lin Z, Moreno Gonzalez C, Serio A, Sreedharan J, Barmada SJ. Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS. Journal of Clinical Investigation. First online 2019 Nov 12. pii: 130988.
Figure published: Weskamp K, Tank EM, Miguez R, McBride JP, Gómez NB, White M, Lin Z, Moreno Gonzalez C, Serio A, Sreedharan J, Barmada SJ. Shortened TDP43 isoforms upregulated by neuronal hyperactivity drive TDP43 pathology in ALS. Journal of Clinical Investigation. First online 2019 Nov 12. pii: 130988.
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Catalogue Number 157962
Applications IHC WB
Antigen/Gene or Protein Targets Shortened TAR DNA-binding protein of 43 kDa (sTDP43)
Relevance This polyclonal antibody recognizes the shortened isoform of the TDP43 protein that is involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia.
Host Rabbit
Immunogen EGFP fused to the 18-amino acid C-terminus of sTDP43
Research Area Neurobiology
Immunogen UniProt ID TADBP_HUMAN

References

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References: 1 entry

Weskamp et al. 2020. J Clin Invest. 130(3):1139-1155. PMID: 31714900.

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References: 1 entry

Weskamp et al. 2020. J Clin Invest. 130(3):1139-1155. PMID: 31714900.

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