| Catalogue Number | 157995 |
| Antigen/Gene or Protein Targets | Targeting HIV-1 protease using HIV1 PR specific inhibitor |
| Synonyms | HIV-1 PR; HIV-1 protease; HIV-2 protease; HIV1 PR; HIV2 PR; HIV1 protease |
| Relevance |
HIV-1 protease is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. - iBodies® are capable of replacing antibodies in biomedical applications such as ELISA, flow cytometry, confocal microscopy, immunocytochemistry, Western Blot and immunoprecipitation. - These iBodies® consist of an N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer decorated with low-molecular-weight compounds that function as targeting ligand (e.g., enzyme inhibitors, receptor ligands), affinity anchor (e.g., biotin) and/or imaging probe (various fluorophores). - These iBodies® have been used for enzyme inhibition, protein isolation, immobilization, quantification and live cell imaging as well as for classical Western Blot application. The system is remarkably modular and can be used for different biological/biochemistry assays. |
| Research Area | Cell Cycle, Cell Signaling & Signal Transduction, Immunology, Virology |
| Notes | iBodies(R) is a registered trade mark of IOCB Tech s.r.o. |
Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.
Šimon et al. 2018. ACS Chem Biol. 13(12):3333-3342. PMID: 30489064.
Dvořáková et al. 2017. J Med Chem. 60(20):8385-8393. PMID: 28953383.
Šácha et al. 2016. Angew Chem Int Ed Engl. 55(7):2356-60. PMID: 26749427.
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Jan Tykvart |
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Frantisek Sedlak |
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Pavel Majer |
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Petr Cigler |
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Vaclav Navratil |
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Vladimir Subr |
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Karel Ulbich |
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Jiri Strohalm |
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Jan Konvalinka |
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Jiří Schimer |
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Tomas Knedlik |
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Sacha Pavel |
