p110beta PI3K-D931A (129)
Invented by Bart Vanhaesebroeck
Invented at Ludwig Institute for Cancer Research
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- References (2)
- Inventor Info
Info
| Catalogue Number | 158388 |
| Antigen/Gene or Protein Targets | PIK3CB |
| Model | Knock-In |
| Production Details | Knock-in mice in which the endogenous PIK3CB/p110beta PI3K gene is mutated so that it now encodes a p110beta protein with the D931A mutation in the ATP binding site, converting it to a kinase-dead p110beta protein which is expressed at the same level as wild-type p110beta. These mice have been backcrossed onto the sv129 background. |
| Mouse Genetic Background/Cross History | Backcrossed onto sv129 for more than 10 generations. |
| Research Area | Cancer |
| Notes | Mice show prenatal partial lethality at at different embryonic stages (see PMID 26132308 for details). Homozygous male mice that are born are infertile with smaller than normal testicles. They cannot produce offspring. |
References: 2 entries
Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.
Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
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References: 2 entries
Guillermet-Guibert et al. 2015. PLoS Genet. 11(7):e1005304. PMID: 26132308.
Kulkarni et al. 2011. Sci Signal. 4(168):ra23. PMID: 21487106.
Add a reference
Inventor Information
Inventors
|
Bart Vanhaesebroeck |
