- Datasheet
- References (1)
- Inventor Info
Info
![Image thumbnail for Anti-Cadherin 6 [2B6-D8] monoclonal antibody](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/92011ca6-308c-4826-ab54-880b8cca8442.png)
| Catalogue Number | 160536 |
| Applications | IHC |
| Antigen/Gene or Protein Targets | Cadherin-6 |
| Synonyms | Cadherin 6, CDH6 |
| Reactivity | N/A |
| Relevance |
From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "In many carcinomas, E-cadherin is considered to be a prognostic marker for patient survivals, and its decreased expression is associated with metastatic disease. Among renal cell carcinomas (RCCs), however, only 20% of tumors express E-cadherin, whereas a much higher percentage express other cadherins, e.g., N-cadherin and cadherin-6. Among these cadherins expressed in RCCs, cadherin-6 has been identified as a major cadherin in the renal proximal tubules and in the tumors themselves." The inventors of this reagent found that " These results suggest that cadherin-6 is a major cadherin playing an essential role in cell-cell adhesion in E-cadherin-absent RCC." |
| Host | Mouse |
| Immunogen | glutathione S-transferase (GST) fusion extracellular domain of human cadherin-6a |
| Myeloma Used | Sp2/0-Ag14 |
| Strain | Balb/c |
| Notes |
From Shimazui et al Clin Cancer Res. 1998 Oct;4(10):2419-24. "Immunohistochemically, 2B6-D8 demonstrated cell-cell border staining in the SKRC-33 cell line that expressed cadherin-6 alone." |
| Research Area | Adhesion, Cancer |
