BCH-P-SS pNET cell line
Invented at University Of Birmingham
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Info
| Catalogue Number | 160632 |
| Synonyms | Askin Tumour |
| Host | Human |
| Disease Keywords | Neuroblastoma pNET (peripheral primitive neuroectodermal tumour) |
| Model | Cancer Model |
| Relevance |
Among small blue round cell tumors, primitive neuroectodermal tumors (PNETs) are a group of Ewing sarcoma family of tumors that are highly aggressive, poorly differentiated and form a group of tumors defined by their appearance that are thought to derive from postganglionic parasympathetic primordial cells located throughout the parasympathetic autonomic nervous system. Iran J Pediatr. 2014 Apr; 24(2): 221–222. PMID: 25535544 Neuroblastoma is the most common extracranial solid malignancy in children. The disease possesses a broad range of clinical phenotypes with widely varying prognoses. Standard clinical and pathological assessments do not always differentiate reliably between tumor subtypes and, therefore, genetic markers are now playing an increasingly important role in treatment decisions. |
| Research Area | Cancer |
| Growth/Phenotype Keywords | Cell lines may contain both neuronal and stromal/substrate adherent (N & S) cell types - this is a recognized characteristic of many neuroblastoma cell lines |
| Recommended Growing Conditions | Growth medium: DME/F12+15% fetal calf serum + glutamine + non-essential amino acids. |
| Notes |
Tissue Site: Chest Wall Patient Sex: Female Neuroblastoma cells have been used for the following: - Investigation of metabolic profiles generated by in vitro H MRS - Characterisation of genetic pathways - Discovery of epigenetically deregulated genes during neuroblastoma tumorigenesis, using genome wide DNA methylation analysis - Functional investigation of MEGF10 knockdown Karyotype data available on request STR data available on request |
| Cellosaurus ID | TBC |
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