HEK293-CEACAM6-Fc cell line
Invented at LeukoCom
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Info
| Catalogue Number | 160695 |
| Antigen/Gene or Protein Targets | CEACAM6 |
| Parental Line | HEK293 |
| Synonyms | Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Cluster of Differentiation 66c |
| Host | Human |
| Tissue | Kidney |
| Model | Transgenic |
| Relevance | CEACAM-6 is expressed by granulocytes and their precursors. Activation enhances surface expression by mobilizing CEACAM-6 from storage in azurophilic granules. It often shows aberrant expression in acute lymphocytic leukaemia's. CEACAM-6 is also expressed in epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas and hyperplastic polyps. Over-expression confers resistance to adhesion-related apoptosis (anoikis) in tumour cells |
| Production Details | Overexpression of human CEACAM6-Fc Chimera Protein |
| Conditional | No |
| Research Area | Adhesion, Cancer |
| Growth/Phenotype Keywords | Adherent |
| Recommended Growing Conditions | DMEM + 10% FBS |
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