HEK293-MacCEACAM1-Fc cell line
Invented at LeukoCom
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Info
| Catalogue Number | 160699 |
| Antigen/Gene or Protein Targets | Macaque CEACAM1 |
| Parental Line | HEK293 |
| Synonyms | Carcinoembryonic antigen-related cell adhesion molecule 1, CD66a, Cluster of Differentiation 66a |
| Host | Human |
| Tissue | Kidney |
| Model | Transgenic |
| Relevance | CEACAM-1, also known as CD66a, is an immunoglobulin superfamily protein that is expressed on neutrophils, activated NK cells, bile duct and colonic epithelial cells, and endothelial cells. CEACAM-1 is heavily glycosylated and carries high mannose residues and (sialyl) Lewis-x. It is expressed as at least three soluble and seven transmembrane isoforms, with variations occurring in both the ECD and cytoplasmic region. It engages in homotypic adhesion and heterotypic adhesion with CEACAM-3/CD66d and CEACAM-6/CD66c. On neutrophils, CEACAM-1 additionally binds to dendritic cell DC-SIGN via its Lewis-x moiety, inducing dendritic cell maturation and a subsequent Th1-type response |
| Production Details | Overexpression of macaque CEACAM1-Fc Chimera Protein |
| Conditional | No |
| Research Area | Adhesion, Cancer |
| Growth/Phenotype Keywords | Adherent |
| Recommended Growing Conditions | DMEM + 10% FBS |
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