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Monoclonal Antibodies

Anti-MUC1 [HMFG1]

Invented by Prof Joyce Taylor-Papadimitriou from King's College London , Prof Joy Burchell from King's College London
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
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Catalogue Number 151495
Applications ELISA FACS IHC IF WB
Antigen/Gene or Protein Targets Mucin1 (MUC1)
Synonyms ADMCKD, ADMCKD1, Breast carcinoma associated antigen DF3, Breast carcinoma-associated antigen DF3, CA 15-3, CA15 3, CA15 3 antigen, CA15.3, Cancer antigen 15-3, Carcinoma associated mucin, Carcinoma-associated mucin, CD 227, CD227
Reactivity Human
Relevance Mucin-1 (MUC1) is a membrane protein present on normal human breast epithelial cells and cell lines derived from breast carcinomas. Human MUC1 is also localised on the surface of the human milk fat globule. MUC1 is a differentiation marker and specific breast epithelial marker in normal and neoplastic mammary development. It is upregulated in the lactating breast and in carcinomas.
Host Mouse
Immunogen Delipidated human milk fat globule.
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Clone also known as "1.10.F3".
Research Area Cancer, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction

References

There are 13 reference entries for this reagent.

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References: 13 entries

Burchell et al. 1993. Epithelial Cell Biol. 2(4):155-62. PMID: 7505698.

FACS

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Effect of modification of carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product.

Europe PMC ID: 7505698

View  

Moss et al. 1988. Lung Cancer. 4, 76-78.

Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.

View  

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

Europe PMC ID: 2443241

View  

Chang et al. 1986. Biochim Biophys Acta. 823(3):161-94. PMID: 2423124.

View  

In vitro transformation of human epithelial cells.

Europe PMC ID: 2423124

View  

Burchell et al. 1983. J Immunol. 131(1):508-13. PMID: 6190927.

View  

Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

Europe PMC ID: 6190927

View  

Taylor-Papadimitriou et al. 1981. Int J Cancer. 28(1):17-21. PMID: 7309278.

View  

Arklie et al. 1981. Int J Cancer. 28(1):23-9. PMID: 6273328.

View  

Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers.

Europe PMC ID: 6273328

View  

Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

Europe PMC ID: 7309278

View  

Add a reference

References: 13 entries

Burchell et al. 1993. Epithelial Cell Biol. 2(4):155-62. PMID: 7505698.

FACS

View  

Effect of modification of carbohydrate side chains on the reactivity of antibodies with core-protein epitopes of the MUC1 gene product.

View  

Moss et al. 1988. Lung Cancer. 4, 76-78.

Burchell et al. 1987. Cancer Res. 47(20):5476-82. PMID: 2443241.

View  

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

View  

Chang et al. 1986. Biochim Biophys Acta. 823(3):161-94. PMID: 2423124.

View  

In vitro transformation of human epithelial cells.

View  

Burchell et al. 1983. J Immunol. 131(1):508-13. PMID: 6190927.

View  

Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells.

View  

Taylor-Papadimitriou et al. 1981. Int J Cancer. 28(1):17-21. PMID: 7309278.

View  

Arklie et al. 1981. Int J Cancer. 28(1):23-9. PMID: 6273328.

View  

Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers.

View  

Monoclonal antibodies to epithelium-specific components of the human milk fat globule membrane: production and reaction with cells in culture.

View  

Add a reference

Inventor Information