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Cell Lines

BICR 10 Cell Line

Invented by Prof Eric Kenneth Parkinson from Queen Mary University of London
Invented at Cancer Research UK Glasgow: The Beatson Institute
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BICR 10 Cell Line. Image courtesy of the European Collection of Authenticated Cell Cultures (ECACC)
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Catalogue Number 152841
Host Human
Tissue Buccal mucosa
Disease Keywords Buccal mucosa squamous carcinoma
Model Tumour line
Relevance Adherent keratinocyte cell line derived from a recurrent squamous cell carcinoma of the buccal mucosa of a Caucasian female. Keratin and involucrin markers present. Known mutations: p53, p16 and p14ARF. Cells are tumourigenic in athymic mice.
Research Area Apoptosis and Programmed Cell Death, Cancer, Drug Discovery & Development, Epigenetics & Nuclear Signalling
Growth/Phenotype Keywords Adherent
Recommended Growing Conditions DMEM + 2mM Glutamine + 10% Foetal Bovine Serum (FBS) + 0.4 micrograms/ml Hydrocortisone.
Notes STR-PCR Data:
Amelogenin: X
CSF1PO: 12,14
D13S317: 8,14
D16S539: 9,13
D5S818: 11,13
D7S820: 11,12
THO1: 9.3
TPOX: 8
vWA: 17
Cellosaurus ID CVCL_2307

References

There are 2 reference entries for this reagent.

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References: 2 entries

Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.

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Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

Europe PMC ID: 7646764

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References: 2 entries

Edington et al. 1995. Mol Carcinog. 13(4):254-65. PMID: 7646764.

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Cellular immortality: a late event in the progression of human squamous cell carcinoma of the head and neck associated with p53 alteration and a high frequency of allele loss.

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Inventor Information