UM-UC-1 (Human bladder transitional cell carcinoma) cell line
Invented at University Of Michigan
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 160436 |
| Synonyms | UM-UC-1 |
| Host | Human |
| Tissue | Lymphatic Tissue |
| Disease Keywords | Human bladder translational cell carcinoma |
| Model | Cancer Model |
| Relevance |
UM-UC-1 are a human transitional cell carcinoma originating from lymphatic metastasis of transitional cell carcinoma of the bladder of a 26-year old black male. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish common observed phenomena across cells of the same type of neoplasm. Tumorigenicity studies in nude mice revealed the UM-UC-1 produced tumors, 1-1.5 cm in diameter in < 3 weeks. UM-UC-1 was more resistant to adenoviral gene transduction than several of the other cells evaluated. UM-UC-1 did, however, have one of the highest levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. |
| Research Area | Cancer |
| Growth/Phenotype Keywords | Adherent |
| Recommended Growing Conditions | Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37C in 5% CO2 environment. |
References: 2 entries
Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
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References: 2 entries
Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
Add a reference
