UM-UC-11 (Human transitional cell carcinoma of the bladder) cell line
Invented at University Of Michigan
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 160441 |
| Synonyms | UM-UC-11 |
| Host | Human |
| Tissue | Bladder |
| Disease Keywords | Human bladder transitional cell carcinoma |
| Model | Cancer Model |
| Relevance |
UM-UC-11 are a human transitional cell carcinoma of the bladder. These cells were assessed for their susceptibility to adenoviral mediated gene delivery, tumor growth in nude mice and differences in genetic alterations. Tumorigenicity studies in nude mice revealed the UM-UC-11 do not produce tumors, even after extended observation. UM-UC-11 demonstrated efficient gene transduction via an adenoviral vector when compared to several of the other cells evaluated. UM-UC-11 also showed intermediate levels of Coxsackie adenovirus receptor (CAR) expression of the cells tested. These assays allowed for characterization of some of the most important features in each of the respective lines in an effort to more accurately establish commonly observed phenomena across cells of the same type of neoplasm. |
| Research Area | Cancer |
| Growth/Phenotype Keywords | Adherent |
| Recommended Growing Conditions | Cells were grown in Dulbecco's modified Eagle's medium (DMEM) containing 10% heat inactivated Fetal Bovine Serum (FBS) and were supplemented with 1% penicillin and streptomycin at 37C in 5% CO2 environment. |
References: 2 entries
Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
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References: 2 entries
Sabichi et al. 2006. J Urol. 175(3 Pt 1):1133-7. PMID: 16469639.
Grossman et al. 1984. J Urol. 132(4):834-7. PMID: 6471236.
Add a reference
